Recurrence after Treatment for Pulmonary Multidrug‐Resistant Tuberculosis | Zendy

Mercedes C. Becerra | Zendy; Sasha C. Appleton | Zendy; Molly F. Franke | Zendy; Katiuska Chalco | Zendy; Jaime Bayona | Zendy; Megan Murray | Zendy; Carole D. Mitnick | Zendy

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Recurrence after Treatment for Pulmonary Multidrug‐Resistant Tuberculosis

Author(s) -

Mercedes C. Becerra,

Sasha C. Appleton,

Molly F. Franke,

Katiuska Chalco,

Jaime Bayona,

Megan Murray,

Carole D. Mitnick

Publication year - 2010

Publication title -

clinical infectious diseases

Language(s) - Uncategorized

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1086/655892

Subject(s) - medicine , tuberculosis , confidence interval , pulmonary tuberculosis , multiple drug resistance , culture conversion , surgery , pediatrics , drug resistance , pathology , microbiology and biotechnology , biology

We estimated the proportion of recurrence within 2 years among adults cured by individualized multidrug-resistant tuberculosis regimens in Peru. Among 310 individuals with at least 24 months of follow-up, 16 experienced an episode of recurrent tuberculosis. If we assume the worst for treatment effectiveness-that all 16 episodes were caused by the original tuberculosis strain-then 5.2% (95% confidence interval, 3.0%-8.2%) experienced true relapse. This is an upper-bound estimate of relapse on which new regimens must improve.

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