HIV‐1 Reverse Transcriptase Connection Domain Mutations: Dynamics of Emergence and Implications for Success of Combination Antiretroviral Therapy | Zendy

Viktor von Wyl | Zendy; Maryam Ehteshami | Zendy; Lisa M. Demeter | Zendy; Philippe Bürgisser | Zendy; Monique Nijhuis | Zendy; Jori Symons | Zendy; Sabine Yerly | Zendy; Jürg Böni | Zendy; Thomas Klimkait | Zendy; Rob Schuurman | Zendy; Bruno Ledergerber | Zendy; Matthias Götte | Zendy; Huldrych F. Günthard | Zendy

Open Access

HIV‐1 Reverse Transcriptase Connection Domain Mutations: Dynamics of Emergence and Implications for Success of Combination Antiretroviral Therapy

Author(s) -

Viktor von Wyl,

Maryam Ehteshami,

Lisa M. Demeter,

Philippe Bürgisser,

Monique Nijhuis,

Jori Symons,

Sabine Yerly,

Jürg Böni,

Thomas Klimkait,

Rob Schuurman,

Bruno Ledergerber,

Matthias Götte,

Huldrych F. Günthard

Publication year - 2010

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1086/655764

Subject(s) - resistance mutation , zidovudine , lamivudine , reverse transcriptase , cart , medicine , drug resistance , virology , mutation , reverse transcriptase inhibitor , genotype , antiretroviral therapy , virus , viral load , genetics , biology , gene , rna , viral disease , hepatitis b virus , mechanical engineering , engineering

Factors promoting the emergence of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) connection domain mutations and their effect on antiretroviral therapy (ART) are still largely undetermined. We investigated this matter by analyzing genotypic resistance tests covering 400 amino acid positions in the RT of HIV-1 subtype B viruses and corresponding treatment histories and laboratory measurements.

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