Systematic Review and Meta‐analysis: Renal Safety of Tenofovir Disoproxil Fumarate in HIV‐Infected Patients | Zendy

Ryan Cooper | Zendy; Natasha Wiebe | Zendy; Nathaniel Smith | Zendy; Philip Keiser | Zendy; Saraladevi Naicker | Zendy; Marcello Tonelli | Zendy

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Systematic Review and Meta‐analysis: Renal Safety of Tenofovir Disoproxil Fumarate in HIV‐Infected Patients

Author(s) -

Ryan Cooper,

Natasha Wiebe,

Nathaniel Smith,

Philip Keiser,

Saraladevi Naicker,

Marcello Tonelli

Publication year - 2010

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1086/655681

Subject(s) - medicine , renal function , nephrotoxicity , cochrane library , confidence interval , meta analysis , randomized controlled trial , hypophosphatemia , creatinine , adverse effect , relative risk , kidney

The efficacy of tenofovir disoproxil fumarate (TDF) as part of combination antiretroviral treatment (ART) has been demonstrated in several randomized, controlled trials. However, an increasing number of case reports suggest that TDF use may be associated with significant nephrotoxicity. Our objective was to determine the renal safety of TDF-containing ART regimens for HIV-infected individuals.

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