Molecular Identification ofTrypanosoma cruziDiscrete Typing Units in End‐Stage Chronic Chagas Heart Disease and Reactivation after Heart Transplantation | Zendy

Juan M. Burgos | Zendy; Mirta Díez | Zendy; Carlos Vigliano | Zendy; Margarita Bisio | Zendy; Marikena G. Risso | Zendy; Tomás Duffy | Zendy; Carolina Cura | Zendy; Betina Brusses | Zendy; Liliana Favaloro | Zendy; María Susana Leguizamón | Zendy; Raúl Horacio Lucero | Zendy; Rubén P. Laguens | Zendy; Mariano Jorge Levin | Zendy; Roberto Favaloro | Zendy; Alejandro G. Schijman | Zendy

Open Access

Molecular Identification ofTrypanosoma cruziDiscrete Typing Units in End‐Stage Chronic Chagas Heart Disease and Reactivation after Heart Transplantation

Author(s) -

Juan M. Burgos,

Mirta Díez,

Carlos Vigliano,

Margarita Bisio,

Marikena G. Risso,

Tomás Duffy,

Carolina Cura,

Betina Brusses,

Liliana Favaloro,

María Susana Leguizamón,

Raúl Horacio Lucero,

Rubén P. Laguens,

Mariano Jorge Levin,

Roberto Favaloro,

Alejandro G. Schijman

Publication year - 2010

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1086/655680

Subject(s) - chagas disease , trypanosoma cruzi , heart transplantation , typing , transplantation , myocarditis , genotype , biology , medicine , immunology , pathology , genetics , parasite hosting , gene , world wide web , computer science

One hundred years after the discovery of Chagas disease, it remains a major neglected tropical disease. Chronic Chagas heart disease (cChHD) is the most severe manifestation. Heart transplantation is the proper treatment for end-stage heart failure, although reactivation of disease may result after receipt of immunosuppressive therapy. T. cruzi strains cluster into 6 discrete typing units (DTUs; I-VI) associated with different geographical distribution, transmission cycles and varying disease symptoms. In the southern cone of South America, T. cruzi II, V, and VI populations appear to be associated with Chagas disease and T. cruzi I with sylvatic cycles.

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