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The reactivation of tuberculosis arises in persons who are latently infected and in those who have been previously treated. The mechanism of the reactivation of tuberculosis in either situation is not well understood. A 13-gene mce1 operon of Mycobacterium tuberculosis was previously shown to be associated with latent infection in mice and may also play a role in reactivation.

Posttreatment Reactivation of Tuberculosis in Mice Caused byMycobacterium tuberculosisDisrupted inmce1R