Absence of Neuroinvasive Disease in a Liver Transplant Recipient Who Acquired West Nile Virus (WNV) Infection from the Organ Donor and Who Received WNV Antibodies Prophylactically | Zendy

Maria Cristina Morelli | Zendy; Vittorio Sambri | Zendy; Gian Luca Grazi | Zendy; Paolo Gaibani | Zendy; Anna Pierro | Zendy; Matteo Cescon | Zendy; Giorgio Ercolani | Zendy; Francesca Cavrini | Zendy; Giada Rossini | Zendy; Maria Rosaria Capobianchi | Zendy; Antonino Di | Zendy; Stefano Menzo | Zendy; P Pagliaro | Zendy; F Ghinelli | Zendy; Tiziana Lazzarotto | Zendy; Maria Paola Landini | Zendy; Antonio Daniele Pinna | Zendy

Open Access

Absence of Neuroinvasive Disease in a Liver Transplant Recipient Who Acquired West Nile Virus (WNV) Infection from the Organ Donor and Who Received WNV Antibodies Prophylactically

Author(s) -

Maria Cristina Morelli,

Vittorio Sambri,

Gian Luca Grazi,

Paolo Gaibani,

Anna Pierro,

Matteo Cescon,

Giorgio Ercolani,

Francesca Cavrini,

Giada Rossini,

Maria Rosaria Capobianchi,

Antonino Di,

Stefano Menzo,

P Pagliaro,

F Ghinelli,

Tiziana Lazzarotto,

Maria Paola Landini,

Antonio Daniele Pinna

Publication year - 2010

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1086/655146

Subject(s) - medicine , asymptomatic , virology , west nile virus , antibody , liver transplantation , asymptomatic carrier , transplantation , virus , viral disease , immunology , disease , organ transplantation , pathology

We describe the first case of West Nile virus (WNV) infection in Europe with transmission from donor to recipient following liver transplantation. The infection was detected in the recipient 3 days after transplantation, during the asymptomatic phase. We also report an innovative prophylactic strategy based on infusion of WNV hyperimmune plasma and gamma globulins that could be effective in preventing the appearance of a neuroinvasive disease.

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