Proteomic Analysis of Cerebrospinal Fluid in Pneumococcal Meningitis Reveals Potential Biomarkers Associated with Survival | Zendy

U. R. Goonetilleke | Zendy; Matthew Scarborough | Zendy; Stephen A. Ward | Zendy; Stephen B. Gordon | Zendy

Open Access

Proteomic Analysis of Cerebrospinal Fluid in Pneumococcal Meningitis Reveals Potential Biomarkers Associated with Survival

Author(s) -

U. R. Goonetilleke,

Matthew Scarborough,

Stephen A. Ward,

Stephen B. Gordon

Publication year - 2010

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/654819

Subject(s) - meningitis , cerebrospinal fluid , medicine , streptococcus pneumoniae , pathogenesis , immunology , pathophysiology , antibiotics , gastroenterology , biology , microbiology and biotechnology , pediatrics

Patients with pneumococcal meningitis often die or have severe neurological damage despite optimal antibiotic therapy. New or improved therapy is required. The delivery of new interventions will require an improved understanding of the disease pathogenesis. Our objective was to learn more about the pathophysiology of severe meningitis through the interpretation of differences in the proteomic profile of cerebrospinal fluid (CSF) from patients with meningitis.

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