Open AccessOn the Cytoadhesion ofPlasmodium vivax–Infected Erythrocytes
Author(s) -
Bruna O. Carvalho,
Stefanie Costa Pinto Lopes,
Paulo Afonso Nogueira,
Patrícia Puccinelli Orlandi,
Daniel Y. Bargieri,
Yara C. Blanco,
Ronei Luciano Mamoni,
Juliana Almeida Leite,
Maurício M. Rodrigues,
Irene S. Soares,
Tatiane Rodrigues de Oliveira,
Gerhard Wunderlich,
Marcus Lacerda,
Hernando A. del Portillo,
Maria Ophelia Galvāo de Araujo,
Bruce Russell,
Rossarin Suwanarusk,
Georges Snounou,
Laurent Rénia,
Fábio Trindade Maranhão Costa
Publication year - 2010
Publication title -
the journal of infectious diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.69
H-Index - 252
eISSN - 1537-6613
pISSN - 0022-1899
DOI - 10.1086/654815
Subject(s) - biology , plasmodium vivax , plasmodium falciparum , malaria , apicomplexa , pathogenesis , immunology , virology , parasitemia
Plasmodium falciparum and Plasmodium vivax are responsible for most of the global burden of malaria. Although the accentuated pathogenicity of P. falciparum occurs because of sequestration of the mature erythrocytic forms in the microvasculature, this phenomenon has not yet been noted in P. vivax. The increasing number of severe manifestations of P. vivax infections, similar to those observed for severe falciparum malaria, suggests that key pathogenic mechanisms (eg, cytoadherence) might be shared by the 2 parasites.
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