Effect of Host Genetics on the Development of Cytomegalovirus Retinitis in Patients with AIDS | Zendy

Efe Sezgın | Zendy; Douglas A. Jabs | Zendy; Sher L. Hendrickson | Zendy; Mark L. Van Natta | Zendy; Alexander Zdanov | Zendy; Richard A. Lewis | Zendy; Michael W. Smith | Zendy; Jennifer L. Troyer | Zendy; Stephen J. O’Brien | Zendy

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Effect of Host Genetics on the Development of Cytomegalovirus Retinitis in Patients with AIDS

Author(s) -

Efe Sezgın,

Douglas A. Jabs,

Sher L. Hendrickson,

Mark L. Van Natta,

Alexander Zdanov,

Richard A. Lewis,

Michael W. Smith,

Jennifer L. Troyer,

Stephen J. O’Brien

Publication year - 2010

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/654814

Subject(s) - retinitis , cytomegalovirus retinitis , haplotype , human cytomegalovirus , cytomegalovirus , biology , immunology , immune system , virology , genetics , genotype , gene , virus , herpesviridae , viral disease

Cytomegalovirus (CMV) retinitis is a common opportunistic infection among patients with AIDS and still causes visual morbidity despite the wide spread usage of highly active antiretroviral therapy (HAART). The ubiquitous CMV pathogen contains a human interleukin-10 (IL-10) homolog in its genome and utilizes it to evade host immune reactions through an IL-10 receptor mediated immune-suppression pathway.

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