Radioimmunotherapy Is More Effective than Antifungal Treatment in Experimental Cryptococcal Infection | Zendy

Ruth Bryan | Zendy; Zewei Jiang | Zendy; Robertha C. Howell | Zendy; Aliyah Morgenstern | Zendy; Frank Bruchertseifer | Zendy; Arturo Casadevall | Zendy; Ekaterina Dadachova | Zendy

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Radioimmunotherapy Is More Effective than Antifungal Treatment in Experimental Cryptococcal Infection

Author(s) -

Ruth Bryan,

Zewei Jiang,

Robertha C. Howell,

Aliyah Morgenstern,

Frank Bruchertseifer,

Arturo Casadevall,

Ekaterina Dadachova

Publication year - 2010

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/654813

Subject(s) - cryptococcus neoformans , amphotericin b , cryptococcosis , radioimmunotherapy , microbiology and biotechnology , in vivo , mycosis , cryptococcus , antifungal , biology , immunology , medicine , antibody , monoclonal antibody

Radioimmunotherapy (RIT) prolongs the survival of mice infected with Cryptococcus neoformans. To compare the efficacy of RIT with that of amphotericin B, we infected AJ/Cr mice intravenously with either nonmelanized or melanized C. neoformans cells. Infected mice were either left untreated or treated 24 h after infection with (213)Bi-18B7 antibody, amphotericin B, or both. Melanization before infection did not increase resistance of C. neoformans to RIT in vivo. (213)Bi-18B7 treatment almost completely eliminated colony-forming units from the lung and brain, whereas amphotericin B did not decrease the number of colony-forming units. We conclude that RIT is more effective than amphotericin B against systemic infection with C. neoformans.

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