Increases in Levels of Schistosome‐Specific Immunoglobulin E and CD23+B Cells in a Cohort of Kenyan Children Undergoing Repeated Treatment and Reinfection withSchistosoma mansoni | Zendy

Carla L. Black | Zendy; Erick M. O. Muok | Zendy; Pauline N. M. Mwinzi | Zendy; Jennifer M. Carter | Zendy; Diana M. S. Karanja | Zendy; W. Evan Secor | Zendy; Daniel G. Colley | Zendy

Open Access

Increases in Levels of Schistosome‐Specific Immunoglobulin E and CD23⁺B Cells in a Cohort of Kenyan Children Undergoing Repeated Treatment and Reinfection withSchistosoma mansoni

Author(s) -

Carla L. Black,

Erick M. O. Muok,

Pauline N. M. Mwinzi,

Jennifer M. Carter,

Diana M. S. Karanja,

W. Evan Secor,

Daniel G. Colley

Publication year - 2010

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/653828

Subject(s) - praziquantel , schistosoma mansoni , schistosomiasis , immunology , immunoglobulin e , cd23 , helminthiasis , antibody , immune system , biology , medicine , helminths

Age prevalence curves for areas in which schistosomiasis is endemic suggest that humans develop partial immunity to reinfection beginning in early adolescence. We conducted a 2-year longitudinal study to determine whether children infected with Schistosoma mansoni develop protection-related immune responses after treatment with praziquantel and whether the development of these immune responses is accelerated by frequent treatment after reinfection.

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