Open AccessAssociation between Breast Milk Erythropoietin and Reduced Risk of Mother‐to‐Child Transmission of HIV
Author(s) -
Joanne E. Arsenault,
Aimee L. Webb,
Irene Koulinska,
Said Aboud,
Wafaie Fawzi,
Eduardo Villamor
Publication year - 2010
Publication title -
the journal of infectious diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.69
H-Index - 252
eISSN - 1537-6613
pISSN - 0022-1899
DOI - 10.1086/653706
Subject(s) - erythropoietin , breast milk , odds ratio , medicine , breast feeding , prospective cohort study , confidence interval , risk factor , breastfeeding , physiology , pregnancy , obstetrics , transmission (telecommunications) , immunology , pediatrics , biology , biochemistry , genetics , electrical engineering , engineering
We examined the prospective associations between breast milk concentrations of erythropoietin, a factor with trophic effects on infant gut epithelia, and the risk of mother-to-child transmission (MTCT) of human immunodeficiency virus (HIV) through breast-feeding in a study of 59 MTCT cases and 116 controls nested within a cohort of antiretroviral-naive HIV-infected Tanzanian women. Controls were matched to cases on the basis of the time from birth when the breast milk sample was collected. The risk of MTCT was inversely related to breast milk erythropoietin concentration (adjusted odds ratio for highest vs lowest erythropoietin concentration tertile, 0.34 [95% confidence interval, 0.14-0.82]; P = .02). These results suggest a protective effect of breast milk erythropoietin against MTCT.
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