Intracellular Casp8p41 Content Is Inversely Associated with CD4 T Cell Count | Zendy

Nathan W. Cummins | Zendy; Wei Jiang | Zendy; John W. McGinty | Zendy; Gary D. Bren | Zendy; Ronald J. Bosch | Zendy; Alan Landay | Zendy; Steven G. Deeks | Zendy; Jeffrey N. Martin | Zendy; Daniel C. Douek | Zendy; Michael M. Lederman | Zendy; Jason M. Brenchley | Zendy; Andrew D. Badley | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Intracellular Casp8p41 Content Is Inversely Associated with CD4 T Cell Count

Author(s) -

Nathan W. Cummins,

Wei Jiang,

John W. McGinty,

Gary D. Bren,

Ronald J. Bosch,

Alan Landay,

Steven G. Deeks,

Jeffrey N. Martin,

Daniel C. Douek,

Michael M. Lederman,

Jason M. Brenchley,

Andrew D. Badley

Publication year - 2010

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/653705

Subject(s) - intracellular , cd8 , t cell , biology , cleavage (geology) , immunology , cell , microbiology and biotechnology , immune system , biochemistry , paleontology , fracture (geology)

Casp8p41 is a protein fragment generated by cleavage of procaspase 8 by human immunodeficiency virus (HIV) protease. We measured Casp8p41 content in memory CD4 T cells and analyzed the association of Casp8p41 content with CD4 T cell count, cross-sectionally and longitudinally. Casp8p41 content was inversely correlated with CD4 T cell count, and change in Casp8p41 content was associated with absolute CD4 T cell count with change over time. Casp8p41 change was a better predictor of CD4 T cell count change than activated CD8 T cell percentage or viral load and was comparable to bacterial 16s DNA levels. This suggests that Casp8p41 is a relevant mediator of CD4 T cell death during HIV infection.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research