Effect of HIV Infection Status and Anti‐Retroviral Treatment on Quantitative and Qualitative Antibody Responses to Pneumococcal Conjugate Vaccine in Infants | Zendy

Shabir A. Madhi | Zendy; Peter V. Adrian | Zendy; Mark F. Cotton | Zendy; James McIntyre | Zendy; Patrick JeanPhilippe | Zendy; Shawn Meadows | Zendy; Sharon Nachman | Zendy; Helena Käyhty | Zendy; Keith P. Klugman | Zendy; Avye Violari | Zendy

Open Access

Effect of HIV Infection Status and Anti‐Retroviral Treatment on Quantitative and Qualitative Antibody Responses to Pneumococcal Conjugate Vaccine in Infants

Author(s) -

Shabir A. Madhi,

Peter V. Adrian,

Mark F. Cotton,

James McIntyre,

Patrick JeanPhilippe,

Shawn Meadows,

Sharon Nachman,

Helena Käyhty,

Keith P. Klugman,

Avye Violari

Publication year - 2010

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/653704

Subject(s) - antibody , medicine , pneumococcal conjugate vaccine , immunology , serotype , virology , immune system , streptococcus pneumoniae , biology , antibiotics , microbiology and biotechnology

Serotype-specific antibody concentration and opsonophagocytic activity (OPA) were evaluated after 3 doses of pneumococcal conjugate vaccine. Groups included human immunodeficiency virus (HIV)-positive infants with CD4(+) cell percentages > or =25% who initiated immediate antiretroviral treatment (the HIV+/ART+ group) or whose antiretroviral treatment was deferred until clinically or immunologically indicated (the HIV+/ART- group). Immune responses were also evaluated in HIV-noninfected infants born to HIV-seronegative (M-/I-) or HIV-positive mothers (M+/I-). Antibody concentrations were similar between HIV+/ART+ and HIV+/ART- infants. However, antibody concentrations were lower in M-/I- infants than in M+/I- infants. Nevertheless, M-/I- infants had superior OPA responses, compared with those in HIV+/ART+ infants, who in turn had better OPA responses, compared with those in HIV+/ART- infants.

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