Open AccessEmergence of New VirulentNeisseria meningitidisSerogroup C Sequence Type 11 Isolates in France
Author(s) -
AlaEddine Deghmane,
Isabelle Parent du Châtelet,
Marek Szatanik,
Eva Hong,
Corinne Ruckly,
Dario Giorgini,
D Lévy-Brühl,
JeanMichel Alonso,
MuhamedKheir Taha
Publication year - 2010
Publication title -
the journal of infectious diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.69
H-Index - 252
eISSN - 1537-6613
pISSN - 0022-1899
DOI - 10.1086/653583
Subject(s) - neisseria meningitidis , virulence , biology , multilocus sequence typing , microbiology and biotechnology , meningococcal disease , virology , incidence (geometry) , neisseriaceae , phenotype , vaccination , genotype , genetics , bacteria , antibiotics , gene , physics , optics
In France, there have been variations in the incidence of invasive meningococcal infection due to serogroup C isolates. Infection peaks were observed in 1992 and 2003 that involved isolates of phenotypes C:2a:P1.5,2 and/or C:2a:P1.5, which belong to the sequence type 11 (ST-11) clonal complex. We report an emergence of isolates belonging to the ST-11 clonal complex since 2003. These isolates displayed a new phenotype, C:2a:P1.7,1, caused infections that occurred as clusters, and were associated with increased infection severity and high virulence in mice. These isolates may be responsible for a peak in the incidence of serogroup C meningococcal infection in France, for which there is no routine vaccination to date.
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