Genetic and Antigenic Diversity of Human Rotaviruses: Potential Impact on Vaccination Programs | Zendy

Carl D. Kirkwood | Zendy

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Genetic and Antigenic Diversity of Human Rotaviruses: Potential Impact on Vaccination Programs

Author(s) -

Carl D. Kirkwood

Publication year - 2010

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/653548

Subject(s) - reassortment , rotavirus , biology , virology , rotavirus vaccine , vaccination , genetic diversity , antigenic variation , virus , medicine , environmental health , population , covid-19 , disease , pathology , infectious disease (medical specialty)

The successful development and implementation of rotavirus vaccines will have a significant impact on rotavirus-induced gastroenteritis in children worldwide. However, this introduction will increase the immune pressure against wild-type rotavirus strains circulating in the community, altering the forces and balances that drive rotavirus evolution. There is concern that antigenically distinct novel or rare strains may be selected and spread, decreasing vaccine efficacy. This review describes the diversity of rotavirus strains and the mechanism by which wild-type rotavirus strains can evolve, including genetic drift and genetic reassortment.

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