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The resistance rate of 67 Mycoplasma pneumoniae isolates from 356 ambulatory adult patients with respiratory tract infection was 69% (46 of 67). All 46 macrolide-resistant strains harbored point mutations in the 23S ribosomal RNA gene. Patients infected with macrolide-resistant M. pneumoniae required significantly longer durations of antibiotic therapy and had longer time to resolution of fever.

clinical infectious diseases/clinical infectious diseases (online. university of chicago. press)

High Prevalence of Macrolide Resistance in<i>Mycoplasma pneumoniae</i>Isolates from Adult and Adolescent Patients with Respiratory Tract Infection in China

High Prevalence of Macrolide Resistance inMycoplasma pneumoniaeIsolates from Adult and Adolescent Patients with Respiratory Tract Infection in China