Epstein‐Barr Virus–Associated Hemophagocytic Lymphohistiocytosis in Adults Characterized by High Viral Genome Load within Circulating Natural Killer Cells | Zendy

Christopher P. Fox | Zendy; C. ShanLowe | Zendy; Philip Gothard | Zendy; Bhuvan Kishore | Zendy; Jeffrey R. Neilson | Zendy; Nathan O’Connor | Zendy; Martin Rowe | Zendy

Open Access

Epstein‐Barr Virus–Associated Hemophagocytic Lymphohistiocytosis in Adults Characterized by High Viral Genome Load within Circulating Natural Killer Cells

Author(s) -

Christopher P. Fox,

C. ShanLowe,

Philip Gothard,

Bhuvan Kishore,

Jeffrey R. Neilson,

Nathan O’Connor,

Martin Rowe

Publication year - 2010

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1086/653424

Subject(s) - hemophagocytic lymphohistiocytosis , epstein–barr virus , virus , context (archaeology) , virology , immunology , medicine , viral load , genome , disease , biology , gene , pathology , genetics , paleontology

Epstein-Barr virus (EBV)-associated hemophagocytic lymphohistiocytosis (HLH) is a rare and aggressive disease usually encountered in the context of primary EBV infection. In most analyzed cases, EBV has been found predominantly in T cells. We describe the novel finding of high EBV genome numbers within circulating natural killer cells in adult patients with EBV-HLH.

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