Cytomegalovirus gN Genotypes Distribution among Congenitally Infected Newborns and Their Relationship with Symptoms at Birth and Sequelae | Zendy

Sara Pignatelli | Zendy; Tiziana Lazzarotto | Zendy; Maria Rosaria Gatto | Zendy; Paola Dal Monte | Zendy; Maria Paola Landini | Zendy; Giacomo Faldella | Zendy; Marcello Lanari | Zendy

Open Access

Cytomegalovirus gN Genotypes Distribution among Congenitally Infected Newborns and Their Relationship with Symptoms at Birth and Sequelae

Author(s) -

Sara Pignatelli,

Tiziana Lazzarotto,

Maria Rosaria Gatto,

Paola Dal Monte,

Maria Paola Landini,

Giacomo Faldella,

Marcello Lanari

Publication year - 2010

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1086/653423

Subject(s) - medicine , cytomegalovirus , population , genotype , human cytomegalovirus , cohort , univariate analysis , confidence interval , disease , pediatrics , logistic regression , immunology , multivariate analysis , herpesviridae , viral disease , biology , virus , genetics , environmental health , gene

Cytomegalovirus (CMV) is the leading cause of congenital infection, with morbidity and mortality at birth and sequelae. Both host and viral factors may affect the outcome of infection. CMV strain virulence may depend on genetic variability in "key genes," such as UL73, which encodes the envelope glycoprotein gN. This study aimed to ascertain the role of gN variants as markers of pathogenicity and prognosis in newborns congenitally infected with CMV.

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