Age‐Related Susceptibility to Severe Malaria Associated with Galectin‐2 in Highland Papuans | Zendy

Louise M. Randall | Zendy; Enny Kenangalem | Zendy; Daniel A. Lampah | Zendy; Emiliana Tjitra | Zendy; Esther D. Mwaikambo | Zendy; Tjandra Handojo | Zendy; Kim A. Piera | Zendy; Zhen Zhao | Zendy; Fabian de Labastida Rivera | Zendy; Yonghong Zhou | Zendy; Karli M. McSweeney | Zendy; Lien Le | Zendy; Fiona H. Amante | Zendy; Ashraful Haque | Zendy; Amanda C. Stanley | Zendy; Tonia Woodberry | Zendy; Ervi Salwati | Zendy; Donald L. Granger | Zendy; Maurine R. Hobbs | Zendy; Ric N. Price | Zendy; J. Brice Weinberg | Zendy; Grant W. Montgomery | Zendy; Nicholas M. Anstey | Zendy; Christian Engwerda | Zendy

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Age‐Related Susceptibility to Severe Malaria Associated with Galectin‐2 in Highland Papuans

Author(s) -

Louise M. Randall,

Enny Kenangalem,

Daniel A. Lampah,

Emiliana Tjitra,

Esther D. Mwaikambo,

Tjandra Handojo,

Kim A. Piera,

Zhen Zhao,

Fabian de Labastida Rivera,

Yonghong Zhou,

Karli M. McSweeney,

Lien Le,

Fiona H. Amante,

Ashraful Haque,

Amanda C. Stanley,

Tonia Woodberry,

Ervi Salwati,

Donald L. Granger,

Maurine R. Hobbs,

Ric N. Price,

J. Brice Weinberg,

Grant W. Montgomery,

Nicholas M. Anstey,

Christian Engwerda

Publication year - 2010

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/653125

Subject(s) - malaria , medicine , environmental health , demography , geography , virology , immunology , sociology

Age and host genetics are important determinants of malaria severity. Lymphotoxin-alpha (LTalpha) has been associated with the development of cerebral malaria (CM) and other severe malaria (SM) syndromes. Mutations in genes regulating LTalpha production contribute to other acute vascular diseases and may contribute to malaria pathogenesis.

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