La Protein Required for Internal Ribosome Entry Site–Directed Translation Is a Potential Therapeutic Target for Hepatitis C Virus Replication | Zendy

Takayoshi Shirasaki | Zendy; Masao Honda | Zendy; Hideki Mizuno | Zendy; Tetsuro Shimakami | Zendy; Hikari Okada | Zendy; Yoshio Sakai | Zendy; Seishi Murakami | Zendy; Takaji Wakita | Zendy; Shuichi Kaneko | Zendy

Open Access

La Protein Required for Internal Ribosome Entry Site–Directed Translation Is a Potential Therapeutic Target for Hepatitis C Virus Replication

Author(s) -

Takayoshi Shirasaki,

Masao Honda,

Hideki Mizuno,

Tetsuro Shimakami,

Hikari Okada,

Yoshio Sakai,

Seishi Murakami,

Takaji Wakita,

Shuichi Kaneko

Publication year - 2010

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/653081

Subject(s) - internal ribosome entry site , virology , telomerase , viral replication , biology , hepatitis c virus , microbiology and biotechnology , rna , ns2 3 protease , translation (biology) , virus , messenger rna , genetics , gene

Translation of the hepatitis C virus (HCV) is mediated by an internal ribosome entry site (IRES). Here, we analyzed the functional relevance of La protein for replication of HCV using an infectious HCV clone, JFH-1.

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