Immune Recovery after Autologous Stem Cell Transplantation Is Not Different for HIV‐Infected versus HIV‐Uninfected Patients with Relapsed or Refractory Lymphoma | Zendy

Cecilia Simonelli | Zendy; Stefania Zanussi | Zendy; Chiara Pratesi | Zendy; Maurizio Rupolo | Zendy; Renato Talamini | Zendy; Cristina Caffau | Zendy; Maria Teresa Bortolin | Zendy; Rosamaria Tedeschi | Zendy; Giancarlo Basaglia | Zendy; M. Mazzucato | Zendy; Rosa Manuele | Zendy; Emanuela Vaccher | Zendy; Michele Spina | Zendy; Umberto Tirelli | Zendy; Mariagrazia Michieli | Zendy; Paolo De Paoli | Zendy

Open Access

Immune Recovery after Autologous Stem Cell Transplantation Is Not Different for HIV‐Infected versus HIV‐Uninfected Patients with Relapsed or Refractory Lymphoma

Author(s) -

Cecilia Simonelli,

Stefania Zanussi,

Chiara Pratesi,

Maurizio Rupolo,

Renato Talamini,

Cristina Caffau,

Maria Teresa Bortolin,

Rosamaria Tedeschi,

Giancarlo Basaglia,

M. Mazzucato,

Rosa Manuele,

Emanuela Vaccher,

Michele Spina,

Umberto Tirelli,

Mariagrazia Michieli,

Paolo De Paoli

Publication year - 2010

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1086/652866

Subject(s) - medicine , autologous stem cell transplantation , immunology , cd8 , transplantation , immune system , population , lymphoma , chemotherapy , refractory (planetary science) , oncology , biology , environmental health , astrobiology

High-dose chemotherapy (HDC) and autologous stem cell transplantation (ASCT) are feasible and effective salvage treatments for human immunodeficiency virus (HIV)-related relapse or refractory lymphoma. Among the main concerns with ASCT in HIV-infected persons is the additional immune depletion caused by treatment, which could amplify the preexisting immune deficit. The aims of our study were to assess the impact of conventional chemotherapy before salvage treatment was administered, in this population, and to evaluate immune reconstitution dynamics during ASCT.

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