Antisense Phosphorodiamidate Morpholino Oligomers Targeted to an Essential Gene InhibitBurkholderia cepaciaComplex | Zendy

David E. Greenberg | Zendy; Kimberly R. MarshallBatty | Zendy; Lauren R. Brinster | Zendy; Kol A. Zarember | Zendy; Pamela A. Shaw | Zendy; Brett L. Mellbye | Zendy; Patrick L. Iversen | Zendy; Steven M. Holland | Zendy; Bruce L. Geller | Zendy

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Antisense Phosphorodiamidate Morpholino Oligomers Targeted to an Essential Gene InhibitBurkholderia cepaciaComplex

Author(s) -

David E. Greenberg,

Kimberly R. MarshallBatty,

Lauren R. Brinster,

Kol A. Zarember,

Pamela A. Shaw,

Brett L. Mellbye,

Patrick L. Iversen,

Steven M. Holland,

Bruce L. Geller

Publication year - 2010

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/652807

Subject(s) - burkholderia cepacia complex , microbiology and biotechnology , morpholino , antimicrobial , biology , virology , burkholderia , gene knockdown , bacteria , gene , biochemistry , genetics

Members of the Burkholderia cepacia complex (Bcc) cause considerable morbidity and mortality in patients with chronic granulomatous disease and cystic fibrosis. Many Bcc strains are antibiotic resistant, which requires the exploration of novel antimicrobial approaches, including antisense technologies such as phosphorodiamidate morpholino oligomers (PMOs).

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