A Substantial Transmission Bottleneck among Newly and Recently HIV‐1–Infected Injection Drug Users in St Petersburg, Russia | Zendy

Alexey Masharsky | Zendy; Elena Dukhovlinova | Zendy; Sergei V. Verevochkin | Zendy; Olga Toussova | Zendy; Roman V. Skochilov | Zendy; Jeffrey A. Anderson | Zendy; Irving Hoffman | Zendy; Myron S. Cohen | Zendy; Ronald Swanstrom | Zendy; Andrei P. Kozlov | Zendy

Open Access

A Substantial Transmission Bottleneck among Newly and Recently HIV‐1–Infected Injection Drug Users in St Petersburg, Russia

Author(s) -

Alexey Masharsky,

Elena Dukhovlinova,

Sergei V. Verevochkin,

Olga Toussova,

Roman V. Skochilov,

Jeffrey A. Anderson,

Irving Hoffman,

Myron S. Cohen,

Ronald Swanstrom,

Andrei P. Kozlov

Publication year - 2010

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/652702

Subject(s) - transmission (telecommunications) , virology , population , sexual transmission , lentivirus , genotype , bottleneck , drug , cohort , human immunodeficiency virus (hiv) , biology , medicine , demography , viral disease , genetics , environmental health , gene , pharmacology , telecommunications , microbicide , computer science , embedded system , sociology

There are limited data on the genetic complexity of human immunodeficiency virus type 1 (HIV-1) after transmission among a cohort of injection drug users (IDUs). We used single-genome amplification of HIV-1 env to determine the genotypic characteristics of virus among IDUs with acute infection in St Petersburg, Russia. Our results indicate that a single variant was transmitted in a majority of cases (9 of 13 participants), which is analogous to what is observed in sexual transmission. These data are most consistent with a genetic bottleneck during transmission by injection drug use that is due to a small inoculum, which most often results in the transmission of a low-complexity viral population.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research