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In 2006, the Centers for Disease Control and Prevention released guidelines recommending that all patients 13–64 years of age be routinely screened for human immunodeficiency virus (HIV) [1], which was followed in 2009 by similar recommendations from the American College of Physicians [2]. Although the overall impact of these statements on HIV testing and diagnosis remains unclear, the 2 statements warrant reflection in light of the findings by Althoff et al [3] published in this issue of Clinical Infectious Diseases. Although few medical conditions have seen such significant and rapid improvements in morbidity and mortality outcomes due to advances in HIV treatment, a large percentage of HIV-infected patients do not benefit if they remain undiagnosed or without HIV care. The poignant question that Althoff et al [3] consider is whether our ability to apply advances in HIV antiretroviral therapy (ART) to our HIV-infected patients has improved along with the effectiveness of therapy. Althoff et al [3] present an analysis of

The Gap between Human Immunodeficiency Virus (HIV) Infection and Advances in HIV Treatment