Genetic Requirements for the Survival of Tubercle Bacilli in Primates | Zendy

Noton K. Dutta | Zendy; Smriti Mehra | Zendy; Peter J. Didier | Zendy; Chad J. Roy | Zendy; Lara A. Doyle | Zendy; Xavier Álvarez | Zendy; Marion S. Ratterree | Zendy; Nicholas A. Be | Zendy; Gyanu Lamichhane | Zendy; Sanjay K. Jain | Zendy; Michelle Lacey | Zendy; Andrew A. Lackner | Zendy; Deepak Kaushal | Zendy

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Genetic Requirements for the Survival of Tubercle Bacilli in Primates

Author(s) -

Noton K. Dutta,

Smriti Mehra,

Peter J. Didier,

Chad J. Roy,

Lara A. Doyle,

Xavier Álvarez,

Marion S. Ratterree,

Nicholas A. Be,

Gyanu Lamichhane,

Sanjay K. Jain,

Michelle Lacey,

Andrew A. Lackner,

Deepak Kaushal

Publication year - 2010

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/652497

Subject(s) - tuberculosis , mycobacterium tuberculosis , virulence , biology , microbiology and biotechnology , in vivo , mutant , immunology , virology , gene , genetics , medicine , pathology

Tuberculosis (TB) leads to the death of 1.7 million people annually. The failure of the bacille Calmette-Guérin vaccine, synergy between AIDS and TB, and the emergence of drug resistance have worsened this situation. It is imperative to delineate the mechanisms employed by Mycobacterium tuberculosis to successfully infect and persist in mammalian lungs.

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