Bacterial Lipoproteins Differentially Regulate Human Primary and Memory CD4+ T and B Cell Responses to Pneumococcal Protein Antigens through Toll‐Like Receptor 2 | Zendy

Qibo Zhang | Zendy; Linda Bagrade | Zendy; Ed Clarke | Zendy; James C. Paton | Zendy; Desmond A. Nunez | Zendy; Adam Finn | Zendy

Open Access

Bacterial Lipoproteins Differentially Regulate Human Primary and Memory CD4+ T and B Cell Responses to Pneumococcal Protein Antigens through Toll‐Like Receptor 2

Author(s) -

Qibo Zhang,

Linda Bagrade,

Ed Clarke,

James C. Paton,

Desmond A. Nunez,

Adam Finn

Publication year - 2010

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/652495

Subject(s) - immunology , memory t cell , memory b cell , immune system , tlr2 , toll like receptor , antibody , biology , antigen , tlr4 , innate immune system , t cell , b cell

Bacterial lipoproteins (BLPs) are expressed across a range of bacteria and are able to activate Toll-like receptor 2 (TLR-2). BLPs enhance immune responses in naive individuals and have therefore been tested as candidate vaccine adjuvants. It is not known whether BLPs affect any preexisting immunity (eg, memory cell response in primed individuals). Colonization with pneumococcus (PNC), which primes for memory cell response, is common in young children.

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