Prions Are Secreted into the Oral Cavity in Sheep with Preclinical Scrapie | Zendy

Ben C. Maddison | Zendy; Helen C. Rees | Zendy; Claire A. Baker | Zendy; Maged M. Taema | Zendy; Susan J Bellworthy | Zendy; Leigh Thorne | Zendy; Linda A. Terry | Zendy; Kevin C. Gough | Zendy

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Prions Are Secreted into the Oral Cavity in Sheep with Preclinical Scrapie

Author(s) -

Ben C. Maddison,

Helen C. Rees,

Claire A. Baker,

Maged M. Taema,

Susan J Bellworthy,

Leigh Thorne,

Linda A. Terry,

Kevin C. Gough

Publication year - 2010

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/652457

Subject(s) - scrapie , virology , prnp , biology , transmission (telecommunications) , genotype , prion protein , disease , medicine , pathology , gene , genetics , electrical engineering , engineering

A major concern in prion disease transmission is the spread of the disease agent by means of secretions and excretions. We analyzed buccal swab samples obtained from preclinical scrapie-infected sheep by concentrating the collected prions on silicon dioxide, followed by amplification by serial protein misfolding cyclic amplification. Data clearly demonstrate that prions are present in buccal swab samples from sheep with a VRQ/VRQ PRNP genotype during preclinical scrapie infection. These data describe for the first time to our knowledge the secretion of prions into the oral cavity of sheep, a finding with implications for the transmission of ovine scrapie and very likely other prion diseases.

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