Protective Immunity to Chlamydial Genital Infection: Evidence from Animal Studies | Zendy

Roger G. Rank | Zendy; Judith A. WhittumHudson | Zendy

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Protective Immunity to Chlamydial Genital Infection: Evidence from Animal Studies

Author(s) -

Roger G. Rank,

Judith A. WhittumHudson

Publication year - 2010

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/652399

Subject(s) - immunity , chlamydial infection , immunology , immune system , sex organ , biology , chlamydia , humoral immunity , cellular immunity , innate immune system , medicine , virology , genetics

In all animal models for chlamydial infection, there is strong evidence for immunity to reinfection; however, immunity is only complete (ie, preventing infection) in the short term. In the long term, animals are only partially immune (ie, they can be reinfected, but infections are usually abbreviated and less intense than the primary infection). This review will target the mechanisms responsible for long-term versus short-term immunity and explore the roles of various components of the host response in immunity to chlamydial genital infection.

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