Antibodies to Chondroitin Sulfate A–Binding Infected Erythrocytes: Dynamics and Protection during Pregnancy in Women Receiving Intermittent Preventive Treatment | Zendy

Elizabeth H. Aitken | Zendy; Bernard Mbewe | Zendy; Mari Luntamo | Zendy; Kenneth Maleta | Zendy; Teija Kulmala | Zendy; MarcJames Friso | Zendy; Freya J. I. Fowkes | Zendy; James G. Beeson | Zendy; Per Ashorn | Zendy; Stephen J. Rogerson | Zendy

Open Access

Antibodies to Chondroitin Sulfate A–Binding Infected Erythrocytes: Dynamics and Protection during Pregnancy in Women Receiving Intermittent Preventive Treatment

Author(s) -

Elizabeth H. Aitken,

Bernard Mbewe,

Mari Luntamo,

Kenneth Maleta,

Teija Kulmala,

MarcJames Friso,

Freya J. I. Fowkes,

James G. Beeson,

Per Ashorn,

Stephen J. Rogerson

Publication year - 2010

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/651578

Subject(s) - pregnancy , malaria , medicine , antibody , gestation , immunology , obstetrics , biology , genetics

Plasmodium falciparum parasites that cause malaria in pregnancy express unique variant surface antigens (VSAs). Levels of immunoglobulin G (IgG) antibody to pregnancy-associated VSAs measured at delivery are gravidity dependent, and they have been associated with protection from disease. It is not known how these IgG responses develop in pregnant women receiving intermittent preventive treatment during pregnancy (IPTp) or whether IgG levels in early pregnancy predict pregnancy outcomes.

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