Effect of Vaccination with Modified Vaccinia Ankara (ACAM3000) on Subsequent Challenge with Dryvax
Author(s) -
Michael S. Seaman,
Marissa B. Wilck,
Lindsey R. Baden,
Stephen R. Walsh,
Lauren E. Grandpre,
Colleen Devoy,
Ayush Giri,
Lizanne C. Noble,
Jane A. Kleinjan,
Kristen E. Stevenson,
Haesook T. Kim,
Raphael Dolin
Publication year - 2010
Publication title -
the journal of infectious diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.69
H-Index - 252
eISSN - 1537-6613
pISSN - 0022-1899
DOI - 10.1086/651560
Subject(s) - vaccinia , modified vaccinia ankara , titer , medicine , smallpox vaccine , virology , vaccination , smallpox , immunization , virus , immunology , neutralizing antibody , antibody , biology , biochemistry , gene , recombinant dna
Despite the success of smallpox vaccination, the immunological correlates of protection are not fully understood. To investigate this question, we examined the effect of immunization with modified vaccinia Ankara (MVA) on subsequent challenge with replication-competent vaccinia virus (Dryvax).
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