Common Polymorphisms in theNOD2Gene Region Are Associated with Leprosy and Its Reactive States | Zendy

William R. Berrington | Zendy; Murdo Macdonald | Zendy; Saraswoti Khadge | Zendy; Bishwa R. Sapkota | Zendy; Marta Janer | Zendy; Deanna A. Hagge | Zendy; Gilla Kaplan | Zendy; Thomas R. Hawn | Zendy

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Common Polymorphisms in theNOD2Gene Region Are Associated with Leprosy and Its Reactive States

Author(s) -

William R. Berrington,

Murdo Macdonald,

Saraswoti Khadge,

Bishwa R. Sapkota,

Marta Janer,

Deanna A. Hagge,

Gilla Kaplan,

Thomas R. Hawn

Publication year - 2010

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/651559

Subject(s) - leprosy , genotype , erythema nodosum , allele , single nucleotide polymorphism , genetic predisposition , nod2 , allele frequency , immunology , case control study , biology , mycobacterium leprae , medicine , genetics , gene , disease , pathology , immune system , innate immune system

Because of its wide spectrum of clinical manifestations and its well-defined immunological complications, leprosy is a useful disease for studying genetic regulation of the host response to infection. We hypothesized that polymorphisms in the nucleotide-binding oligomerization domain containing 2 (NOD2) gene, for a cytosolic receptor known to detect mycobacteria, are associated with susceptibility to leprosy and its clinical outcomes.

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