HIV Infection–Related Tuberculosis: Clinical Manifestations and Treatment | Zendy

Timothy R. Sterling | Zendy; Paul A. Pham | Zendy; Richard E. Chaisson | Zendy

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HIV Infection–Related Tuberculosis: Clinical Manifestations and Treatment

Author(s) -

Timothy R. Sterling,

Paul A. Pham,

Richard E. Chaisson

Publication year - 2010

Publication title -

clinical infectious diseases

Language(s) - Uncategorized

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1086/651495

Subject(s) - medicine , tuberculosis , subclinical infection , disease , immunology , human immunodeficiency virus (hiv) , antiretroviral therapy , drug , viral disease , pharmacotherapy , immunopathology , virology , viral load , pathology , pharmacology

Several aspects of human immunodeficiency virus (HIV) infection-related tuberculosis (TB) and its treatment differ from those of TB in HIV-uninfected persons. The risk of TB and the clinical and radiographic manifestations of disease are primary examples. Antiretroviral therapy has a profound effect on lowering the risk of TB in HIV-infected persons, but it can also be associated with immune reconstitution inflammatory disease and unmasking of previously subclinical disease. There are also differences in treatment of HIV infection-related TB because of overlapping drug toxicities and drug-drug interactions between antiretroviral therapy and anti-TB therapy.

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