Microbial Translocation Correlates with the Severity of Both HIV‐1 and HIV‐2 Infections | Zendy

Salma Nowroozalizadeh | Zendy; Fredrik Månsson | Zendy; Zacarias da Silva | Zendy; Johanna Repits | Zendy; Braima Dabo | Zendy; Carla Pereira | Zendy; Antonio Biague | Zendy; Jan Albert | Zendy; Jens Nielsen | Zendy; Peter Aaby | Zendy; Éva Mária Fenyõ | Zendy; Hans Norrgren | Zendy; Birgitta Holmgren | Zendy; Marianne Jansson | Zendy

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Microbial Translocation Correlates with the Severity of Both HIV‐1 and HIV‐2 Infections

Author(s) -

Salma Nowroozalizadeh,

Fredrik Månsson,

Zacarias da Silva,

Johanna Repits,

Braima Dabo,

Carla Pereira,

Antonio Biague,

Jan Albert,

Jens Nielsen,

Peter Aaby,

Éva Mária Fenyõ,

Hans Norrgren,

Birgitta Holmgren,

Marianne Jansson

Publication year - 2010

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/651430

Subject(s) - immune system , chromosomal translocation , immunology , lipopolysaccharide , viral load , biology , human immunodeficiency virus (hiv) , virus , innate immune system , virology , microbiology and biotechnology , biochemistry , gene

Microbial translocation has been linked to systemic immune activation during human immunodeficiency virus (HIV) type 1 infection. Here, we show that an elevated level of microbial translocation, measured as plasma lipopolysaccharide (LPS) concentration, correlates with AIDS in both individuals infected with HIV type 1 and individuals infected with HIV type 2. LPS concentration also correlates with CD4+ T cell count and viral load independently of HIV type. Furthermore, elevated plasma LPS concentration was found to be concomitant with defective innate and mitogen responsiveness. We suggest that microbial translocation may contribute to loss of CD4+ T cells, increase in viral load, and defective immune stimuli responsiveness during both HIV type 1 and HIV type 2 infections.

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