Average Adherence to Boosted Protease Inhibitor Therapy, rather than the Pattern of Missed Doses, as a Predictor of HIV RNA Replication | Zendy

JeanJacques Parienti | Zendy; Kathleen Ragland | Zendy; F. Lucht | Zendy; Arnaud de La Blanchardière | Zendy; S. Dargère | Zendy; Yazdan Yazdanpanah | Zendy; JeanJacques Dutheil | Zendy; Philippe Van de Perre | Zendy; Renaud Verdon | Zendy; David R. Bangsberg | Zendy

Open Access

Average Adherence to Boosted Protease Inhibitor Therapy, rather than the Pattern of Missed Doses, as a Predictor of HIV RNA Replication

Author(s) -

JeanJacques Parienti,

Kathleen Ragland,

F. Lucht,

Arnaud de La Blanchardière,

S. Dargère,

Yazdan Yazdanpanah,

JeanJacques Dutheil,

Philippe Van de Perre,

Renaud Verdon,

David R. Bangsberg

Publication year - 2010

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1086/651419

Subject(s) - medicine , protease inhibitor (pharmacology) , ritonavir , reverse transcriptase inhibitor , replication (statistics) , virology , viral replication , antiretroviral therapy , reverse transcriptase , protease , cohort , cohort study , viral load , virus , oncology , pharmacology , rna , biology , enzyme , gene , biochemistry

Consecutive missed doses may differentially impact the efficacy of antiretroviral therapy associated with the use of a nonnucleoside reverse-transcriptase inhibitor (NNRTI) and a ritonavir-boosted protease inhibitor (PI). In a cohort of 72 subjects receiving a boosted PI, average adherence to dosage was a better predictor of human immunodeficiency virus (HIV) replication than was the duration or frequency of treatment interruption. In contrast with an NNRTI, consecutive missed doses of a boosted PI did not emerge as a major risk factor for HIV replication.

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