Open AccessHost Determinants of HIV‐1 Control in African Americans
Author(s) -
Kimberly Pelak,
David Goldstein,
Sophie Nicole,
Jacques Fellay,
Dongliang Ge,
Kevin V. Shianna,
Curtis Gumbs,
Xiaojiang Gao,
Jessica M. Maia,
Kenneth Cronin,
S. K. Hussain,
Mary Carrington,
N L Michael,
Amy Weintrob
Publication year - 2010
Publication title -
the journal of infectious diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.69
H-Index - 252
eISSN - 1537-6613
pISSN - 0022-1899
DOI - 10.1086/651382
Subject(s) - snp , single nucleotide polymorphism , genetics , human leukocyte antigen , allele , biology , viral load , human immunodeficiency virus (hiv) , genome wide association study , genome , genetic association , gene , genotype , virology , virus , antigen
We performed a whole-genome association study of human immunodeficiency virus type 1 (HIV-1) set point among a cohort of African Americans (n = 515), and an intronic single-nucleotide polymorphism (SNP) in the HLA-B gene showed one of the strongest associations. We use a subset of patients to demonstrate that this SNP reflects the effect of the HLA-B*5703 allele, which shows a genome-wide statistically significant association with viral load set point (P = 5.6 x 10(-10)). These analyses therefore confirm a member of the HLA-B*57 group of alleles as the most important common variant that influences viral load variation in African Americans, which is consistent with what has been observed for individuals of European ancestry, among whom the most important common variant is HLA-B*5701.
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