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Mutants of the a determinant of hepatitis B surface antigen (HBsAg) can escape neutralization by vaccine-induced antibodies and prevail in an immunized population.

the journal of infectious diseases (online. university of chicago press)/the journal of infectious diseases

No Increase in Prevalence of Hepatitis B Surface Antigen Mutant in a Population of Children and Adolescents Who Were Fully Covered by Universal Infant Immunization