Estrogen Receptor β Agonism Increases Survival in Experimentally Induced Sepsis and Ameliorates the Genomic Sepsis Signature: A Pharmacogenomic Study | Zendy

Eirini Christaki | Zendy; Steven M. Opal | Zendy; James C. Keith | Zendy; Nubar Kessinian | Zendy; John E. Palardy | Zendy; Nicolas A. Parejo | Zendy; Edward R. LaVallie | Zendy; Lisa Racie | Zendy; William Mounts | Zendy; Michael S. Malamas | Zendy; Richard E. Mewshaw | Zendy; Heather A. Harris | Zendy; George P. Vlasuk | Zendy

Open Access

Estrogen Receptor β Agonism Increases Survival in Experimentally Induced Sepsis and Ameliorates the Genomic Sepsis Signature: A Pharmacogenomic Study

Author(s) -

Eirini Christaki,

Steven M. Opal,

James C. Keith,

Nubar Kessinian,

John E. Palardy,

Nicolas A. Parejo,

Edward R. LaVallie,

Lisa Racie,

William Mounts,

Michael S. Malamas,

Richard E. Mewshaw,

Heather A. Harris,

George P. Vlasuk

Publication year - 2010

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/651276

Subject(s) - sepsis , biology , agonist , proinflammatory cytokine , estrogen receptor , transcriptome , estrogen receptor alpha , receptor , estrogen , pharmacology , cancer research , immunology , medicine , inflammation , gene expression , endocrinology , gene , cancer , breast cancer , biochemistry

Nonsteroidal agonists have been developed that selectively bind to and activate estrogen receptor beta (ERbeta) rather than estrogen receptor alpha (ERalpha). ERbeta is expressed equally in both male and female mammals in multiple extragonadal tissues. Work reported elsewhere has demonstrated that ERbeta agonists have beneficial effects in multiple (but not all) models of inflammatory diseases and also increase survival in experimentally induced sepsis.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research