Serological Evidence of Human Hantavirus Infections in Guinea, West Africa | Zendy

Boris Klempa | Zendy; Lamine Koivogui | Zendy; Oumar Sylla | Zendy; Kékoura Koulemou | Zendy; Brita Auste | Zendy; Detlev H. Krüger | Zendy; Jan ter Meulen | Zendy

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Serological Evidence of Human Hantavirus Infections in Guinea, West Africa

Author(s) -

Boris Klempa,

Lamine Koivogui,

Oumar Sylla,

Kékoura Koulemou,

Brita Auste,

Detlev H. Krüger,

Jan ter Meulen

Publication year - 2010

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/651169

Subject(s) - hantavirus , hantavirus infection , serology , virology , antibody , new guinea , serotype , bunyaviridae , hantaan virus , population , medicine , biology , immunology , virus , environmental health , ethnology , history

We recently discovered a novel hantavirus, Sangassou virus, in Guinea, West Africa. Using enzyme-linked immunosorbent assays followed by confirmatory and serotyping assays, we retrospectively detected hantavirus antibodies in 3 (4.4%) of 68 patients with fever of unknown origin in Sangassou village, Forest Guinea. A population-based survey in Forest Guinea (n = 649) found the prevalence of hantavirus antibodies to be 1.2%. Specific neutralizing antibodies against Sangassou virus were demonstrated in serum samples from 2 patients and in 2 serum samples of the serosurvey. Our data allow us to conclude that hantavirus infections may be a significant unrecognized medical problem in at least this part of Africa.

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