Epidemiological and Biological Evidence for a Compensatory Effect of Connection Domain Mutation N348I on M184V in HIV‐1 Reverse Transcriptase | Zendy

Viktor von Wyl | Zendy; Maryam Ehteshami | Zendy; Jori Symons | Zendy; Philippe Bürgisser | Zendy; Monique Nijhuis | Zendy; Lisa M. Demeter | Zendy; Sabine Yerly | Zendy; Jürg Böni | Zendy; Thomas Klimkait | Zendy; Rob Schuurman | Zendy; Bruno Ledergerber | Zendy; Matthias Götte | Zendy; Huldrych F. Günthard | Zendy

Open Access

Epidemiological and Biological Evidence for a Compensatory Effect of Connection Domain Mutation N348I on M184V in HIV‐1 Reverse Transcriptase

Author(s) -

Viktor von Wyl,

Maryam Ehteshami,

Jori Symons,

Philippe Bürgisser,

Monique Nijhuis,

Lisa M. Demeter,

Sabine Yerly,

Jürg Böni,

Thomas Klimkait,

Rob Schuurman,

Bruno Ledergerber,

Matthias Götte,

Huldrych F. Günthard

Publication year - 2010

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/651168

Subject(s) - resistance mutation , zidovudine , lamivudine , reverse transcriptase , virology , reverse transcriptase inhibitor , biology , medicine , human immunodeficiency virus (hiv) , pharmacology , sida , genetics , viral disease , virus , polymerase chain reaction , hepatitis b virus , gene

The connection domain mutation N348I confers resistance to zidovudine (AZT) and is associated with the lamivudine (3TC) mutation M184V. We explored the biochemical and virological influence of N348I in the context of M184V.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research