Quantitative Assessment of Combination Antimicrobial Therapy against Multidrug‐Resistant Bacteria in a Murine Pneumonia Model | Zendy

Zhe Yuan | Zendy; Kimberly R. Ledesma | Zendy; Renu Singh | Zendy; Jingguo Hou | Zendy; Randall A. Prince | Zendy; Vincent H. Tam | Zendy

Open Access

Quantitative Assessment of Combination Antimicrobial Therapy against Multidrug‐Resistant Bacteria in a Murine Pneumonia Model

Author(s) -

Zhe Yuan,

Kimberly R. Ledesma,

Renu Singh,

Jingguo Hou,

Randall A. Prince,

Vincent H. Tam

Publication year - 2010

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/651024

Subject(s) - antimicrobial , acinetobacter baumannii , cefepime , pseudomonas aeruginosa , antibiotics , multiple drug resistance , pneumonia , amikacin , microbiology and biotechnology , medicine , antibiotic resistance , combination therapy , biology , bacteria , pharmacology , imipenem , genetics

Combination antimicrobial therapy is clinically used as a last-resort strategy to control multidrug-resistant bacterial infections. However, selection of antibiotics is often empirical, and conventional assessment of combined drug effect has not been correlated to clinical outcomes. Here, we report a quantitative method to assess combined killing of antimicrobial agents against 2 multidrug-resistant bacteria.

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