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Combination antimicrobial therapy is clinically used as a last-resort strategy to control multidrug-resistant bacterial infections. However, selection of antibiotics is often empirical, and conventional assessment of combined drug effect has not been correlated to clinical outcomes. Here, we report a quantitative method to assess combined killing of antimicrobial agents against 2 multidrug-resistant bacteria.

Quantitative Assessment of Combination Antimicrobial Therapy against Multidrug‐Resistant Bacteria in a Murine Pneumonia Model