Mutations in Extensively Drug‐ResistantMycobacterium tuberculosisThat Do Not Code for Known Drug‐Resistance Mechanisms | Zendy

Alifiya S. Motiwala | Zendy; Yang Dai | Zendy; Edward C. JonesLópez | Zendy; SooHee Hwang | Zendy; Jong Seok Lee | Zendy; Sang Nae Cho | Zendy; Laura E. Via | Zendy; Clifton E. Barry | Zendy; David Alland | Zendy

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Mutations in Extensively Drug‐ResistantMycobacterium tuberculosisThat Do Not Code for Known Drug‐Resistance Mechanisms

Author(s) -

Alifiya S. Motiwala,

Yang Dai,

Edward C. JonesLópez,

SooHee Hwang,

Jong Seok Lee,

Sang Nae Cho,

Laura E. Via,

Clifton E. Barry,

David Alland

Publication year - 2010

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/650999

Subject(s) - biology , mycobacterium tuberculosis , drug resistance , genetics , virology , extensively drug resistant tuberculosis , mutation , tuberculosis , resistance mutation , genome , multiple drug resistance , gene , medicine , polymerase chain reaction , reverse transcriptase , pathology

Highly lethal outbreaks of multidrug-resistant (MDR) and extensively drug-resistant (XDR) tuberculosis are increasing. Whole-genome sequencing of KwaZulu-Natal MDR and XDR outbreak strains prevalent in human immunodeficiency virus (HIV)-infected patients by the Broad Institute identified 22 novel mutations which were unique to the XDR genome or shared only by the MDR and XDR genomes and not already known to be associated with drug resistance.

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