Enhanced Indoleamine 2,3‐Dioxygenase Activity in Patients with Severe Sepsis and Septic Shock | Zendy

Pierre Tattevin | Zendy; Delphine Monnier | Zendy; Olivier Tribut | Zendy; Joëlle Dulong | Zendy; Nadège Bescher | Zendy; Frédéric Mourcin | Zendy; Fabrice Uhel | Zendy; Yves Le Tulzo | Zendy; Karin Tarte | Zendy

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Enhanced Indoleamine 2,3‐Dioxygenase Activity in Patients with Severe Sepsis and Septic Shock

Author(s) -

Pierre Tattevin,

Delphine Monnier,

Olivier Tribut,

Joëlle Dulong,

Nadège Bescher,

Frédéric Mourcin,

Fabrice Uhel,

Yves Le Tulzo,

Karin Tarte

Publication year - 2010

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/650996

Subject(s) - indoleamine 2,3 dioxygenase , sepsis , septic shock , immune system , immunology , catabolism , immune dysregulation , medicine , limiting , shock (circulatory) , tryptophan metabolism , biology , tryptophan , metabolism , biochemistry , amino acid , mechanical engineering , engineering

Severe sepsis results in a sustained deleterious immune dysregulation. Indoleamine 2,3-dioxygenase (IDO), the rate-limiting enzyme of tryptophan catabolism, plays a pivotal role in immune tolerance and is induced during various inflammatory conditions.

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