A Piglet Model of Acute Gastroenteritis Induced byShigella dysenteriaeType 1
Author(s) -
Kwangil Jeong,
Quanshun Zhang,
John Nunnari,
Saul Tzipori
Publication year - 2010
Publication title -
the journal of infectious diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.69
H-Index - 252
eISSN - 1537-6613
pISSN - 0022-1899
DOI - 10.1086/650995
Subject(s) - lamina propria , shigellosis , proinflammatory cytokine , diarrhea , shigella dysenteriae , dysentery , lumen (anatomy) , biology , microbiology and biotechnology , immunology , tumor necrosis factor alpha , pathogenesis , shigella , inflammation , cytokine , shiga toxin , medicine , pathology , epithelium , bacteria , escherichia coli , salmonella , biochemistry , gene , genetics
The lack of a standardized laboratory animal model that mimics key aspects of human shigellosis remains a major obstacle to addressing questions about pathogenesis, screening therapeutics, and evaluation of vaccines.
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