Resistance to Linezolid Is Mediated by thecfrGene in the First Report of an Outbreak of Linezolid‐ResistantStaphylococcus aureus | Zendy

Gracia Morales | Zendy; Juan J. Picazo | Zendy; Elvira Baos | Zendy; Francisco Javier Candel | Zendy; A Arribi | Zendy; B. Armada Peláez | Zendy; Raquel Sales de Andrade | Zendy; M. de la Torre | Zendy; J. Fereres | Zendy; Miguel Sánchez García | Zendy

Open Access

Resistance to Linezolid Is Mediated by thecfrGene in the First Report of an Outbreak of Linezolid‐ResistantStaphylococcus aureus

Author(s) -

Gracia Morales,

Juan J. Picazo,

Elvira Baos,

Francisco Javier Candel,

A Arribi,

B. Armada Peláez,

Raquel Sales de Andrade,

M. de la Torre,

J. Fereres,

Miguel Sánchez García

Publication year - 2010

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1086/650574

Subject(s) - 23s ribosomal rna , linezolid , microbiology and biotechnology , staphylococcus aureus , agar dilution , outbreak , medicine , tigecycline , ribosomal rna , minimum inhibitory concentration , vancomycin , biology , virology , gene , antibiotics , genetics , bacteria , rna , ribosome

From April through June 2008, we identified 12 patients in the intensive care unit and 3 patients on other wards infected with methicillin-resistant Staphylococcus aureus that was also resistant to linezolid. We investigated the mechanism of resistance--point mutations in domain V of 23S ribosomal RNA (rRNA) or presence of the cfr gene--involved in the outbreak.

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