Continuous Infusion of Amphotericin B Deoxycholate in the Treatment of Cryptococcal Meningoencephalitis: Analysis of Safety and Fungicidal Activity | Zendy

Diego R. Falci | Zendy; Luciano Weber Lunardi | Zendy; Carina Ramos | Zendy; Mônica Baumgardt Bay | Zendy; Valério Rodrigues Aquino | Zendy; Luciano Z. Goldani | Zendy

Open Access

Continuous Infusion of Amphotericin B Deoxycholate in the Treatment of Cryptococcal Meningoencephalitis: Analysis of Safety and Fungicidal Activity

Author(s) -

Diego R. Falci,

Luciano Weber Lunardi,

Carina Ramos,

Mônica Baumgardt Bay,

Valério Rodrigues Aquino,

Luciano Z. Goldani

Publication year - 2010

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1086/650489

Subject(s) - amphotericin b , medicine , meningoencephalitis , amphotericin b deoxycholate , mycosis , fungicide , pharmacology , antifungal , gastroenterology , surgery , immunology , dermatology , caspofungin , botany , biology

We measured fungicidal activity of continuous infusion of amphotericin B deoxycholate plus 5'flucytosine using quantitative cultures of cerebrospinal fluid (CSF) obtained from lumbar punctures of human immunodeficiency virus (HIV)-infected patients with neurocryptococcosis during 14 days of treatment. Glomerular renal function was preserved in all patients. Mycological efficacy with progressive reduction in CSF cryptococcal colony-forming units was comparable to standard 4-h infusion of amphotericin B.

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