Effect of the Neuraminidase Mutation H274Y Conferring Resistance to Oseltamivir on the Replicative Capacity and Virulence of Old and Recent Human Influenza A(H1N1) Viruses | Zendy

Mariana Baz | Zendy; Yacine Abed | Zendy; Philippe Simon | Zendy; MarieÈve Hamelin | Zendy; Guy Boivin | Zendy

Open Access

Effect of the Neuraminidase Mutation H274Y Conferring Resistance to Oseltamivir on the Replicative Capacity and Virulence of Old and Recent Human Influenza A(H1N1) Viruses

Author(s) -

Mariana Baz,

Yacine Abed,

Philippe Simon,

MarieÈve Hamelin,

Guy Boivin

Publication year - 2010

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/650464

Subject(s) - neuraminidase , oseltamivir , virology , neuraminidase inhibitor , virus , biology , virulence , microbiology and biotechnology , influenza a virus , viral replication , titer , influenza a virus subtype h5n1 , mutant , gene , medicine , genetics , covid-19 , disease , infectious disease (medical specialty)

The viral fitness of neuraminidase inhibitor (NAI)-resistant influenza viruses is believed to be impaired. Unexpectedly, an oseltamivir-resistant A(H1N1) variant containing the H274Y neuraminidase (NA) mutation recently disseminated worldwide, suggesting that the replication and virulence properties of this mutant virus were not compromised.

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