High Level of Perforin Expression in T Cells: An Early Prognostic Marker of the Severity of Herpesvirus Reactivation after Allogeneic Stem Cell Transplantation in Adults | Zendy

Floor Pietersma | Zendy; Suzanne van Dorp | Zendy; Ronald Jacobi | Zendy; L. Ran | Zendy; Nening M. Nanlohy | Zendy; Rob Schuurman | Zendy; Monique C. Minnema | Zendy; Ellen Meijer | Zendy; D. van Baarle | Zendy

Open Access

High Level of Perforin Expression in T Cells: An Early Prognostic Marker of the Severity of Herpesvirus Reactivation after Allogeneic Stem Cell Transplantation in Adults

Author(s) -

Floor Pietersma,

Suzanne van Dorp,

Ronald Jacobi,

L. Ran,

Nening M. Nanlohy,

Rob Schuurman,

Monique C. Minnema,

Ellen Meijer,

D. van Baarle

Publication year - 2010

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1086/650455

Subject(s) - perforin , viral load , cd8 , cytotoxic t cell , transplantation , medicine , immunology , virology , virus , biology , immune system , biochemistry , in vitro

Epstein-Barr virus (EBV) and cytomegalovirus reactivations are frequent complications of hematopoeitic allogeneic stem cell transplantation (SCT) because of a lack of T cell control after immunosuppression. Early diagnosis of reactivation and subsequent preemptive therapy relies on frequent viral load measurement. Additional virus-specific T cell reconstitution data could improve the predictive value of viral load detection for viral complications after transplantation. Here, we studied perforin expression in CD8(+) T cells as a measure of cytotoxic T cell capacity in relation to the occurrence of viral reactivation.

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