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Vicriviroc in Combination Therapy with an Optimized Regimen for Treatment‐Experienced Subjects: 48‐Week Results of the VICTOR‐E1 Phase 2 Trial
Author(s) -
Jamal Suleiman,
Barry S. Zingman,
Ricardo Sobhie Diaz,
José Valdez Madruga,
Edwin DeJesus,
Jihad Slim,
Carmen Mak,
Erin Lee,
Michael McCarthy,
Lisa M. Dunkle,
Sharon Walmsley
Publication year - 2010
Publication title -
the journal of infectious diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.69
H-Index - 252
eISSN - 1537-6613
pISSN - 0022-1899
DOI - 10.1086/650342
Subject(s) - placebo , regimen , medicine , ritonavir , adverse effect , ccr5 receptor antagonist , viral load , clinical endpoint , indinavir , gastroenterology , protease inhibitor (pharmacology) , randomized controlled trial , clinical trial , human immunodeficiency virus (hiv) , immunology , antiretroviral therapy , pathology , alternative medicine , chemokine , receptor , chemokine receptor
Agents that block the CCR5 coreceptor for human immunodeficiency virus (HIV) have demonstrated potent antiretroviral activity. In early clinical studies, the CCR5 antagonist vicriviroc proved to be a safe and effective component of combination antiretroviral therapy.

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