Paraoxonase‐1 Gene Haplotypes Are Associated with Metabolic Disturbances, Atherosclerosis, and Immunologic Outcome in HIV‐Infected Patients | Zendy

Sandra Parra | Zendy; Judit Marsillach | Zendy; Gerard Aragonès | Zendy; Raúl BeltránDebón | Zendy; Manuel Montero | Zendy; Blai Coll | Zendy; Bharti Mackness | Zendy; Michael I. Mackness | Zendy; Carlos AlonsoVillaverde | Zendy; Jorge Joven | Zendy; Jordi Camps | Zendy

Open Access

Paraoxonase‐1 Gene Haplotypes Are Associated with Metabolic Disturbances, Atherosclerosis, and Immunologic Outcome in HIV‐Infected Patients

Author(s) -

Sandra Parra,

Judit Marsillach,

Gerard Aragonès,

Raúl BeltránDebón,

Manuel Montero,

Blai Coll,

Bharti Mackness,

Michael I. Mackness,

Carlos AlonsoVillaverde,

Jorge Joven,

Jordi Camps

Publication year - 2010

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/650312

Subject(s) - paraoxonase , pon1 , haplotype , oxidative stress , subclinical infection , immunology , aryldialkylphosphatase , gene , medicine , virology , human immunodeficiency virus (hiv) , biology , genetics , allele , genotype

Oxidative stress is associated with human immunodeficiency virus (HIV) infection. Paraoxonase-1 (PON1) is an antioxidant enzyme that is bound to high-density lipoproteins (HDLs). We evaluated whether PON1 gene haplotypes influence the metabolic disturbances, presence of subclinical atherosclerosis, and virologic outcome associated with the infection.

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